For short questions, you can get immediate help by visiting the #python channel. You will need to first register your nickname with FreeNode, using the nickname setup instructions. For more info, see the channel's web site at python-pound.org.
German speakers can use the #python.de channel.
Portuguese speakers can use the #python-pt channel.
Spanish speakers can use the #pyar channel, from the Python Argentina user group.
French speakers can join the #python-fr channel.
Finnish speakers can join the #python.fi channel on a different network, *IRCnet*.
Turkish speakers can join the #python-tr channel.
#python-dev is for CPython developers, where they can coordinate their work or discuss problems. Bots post updates to the channel based on activity in the CPython source tree and bug tracker.
#distutils is for Python packaging discussion.